JZL195 (JJKK-004) | Dual MAGL/FAAH inhibitor | Probechem Biochemicals

Chemical Structure : JZL195

CAS No.: 1210004-12-8

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JZL195 (JJKK-004, JZL 195)

货号: PC-20487Not For Human Use, Lab Use Only.

JZL195 (JJKK-004) is a potent, selective dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

JZL195 (JJKK-004) is a potent, selective dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively.
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL with IC50 of 13 and 19 nM, respectively.
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of 10-100 nM based on competitive ABPP assays.
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assays.

物理化学性质&存储条件

分子量	433.46
分子式	C24H23N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

参考文献

1. Long JZ, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.

JZL195 (JJKK-004, JZL 195)

生物&药学活性

物理化学性质&存储条件

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JZL195 (JJKK-004, JZL 195)

生物&药学活性

物理化学性质&存储条件

参考文献

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