JZL184 | MAGL inhibitor | Probechem Biochemicals

Chemical Structure : JZL184

CAS No.: 1101854-58-3

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JZL184 (JZL 184)

货号: PC-20486Not For Human Use, Lab Use Only.

JZL184 (JZL 184) is a potent, selective and irreversible MAGL inhibitor, blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes with IC50 of 8 nM, >300-fold selectivity for MAGL over FAAH.

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25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2580	In stock
250 mg		Get quote

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生物&药学活性

JZL184 (JZL 184) is a potent, selective and irreversible MAGL inhibitor, blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes with IC50 of 8 nM, >300-fold selectivity for MAGL over FAAH.
JZL184 increases 2-AG but not AEA concentrations in mouse brain.
JZL184-treated mice exhibited a broad array of CB1-dependent behavioral effects, including analgesia, hypothermia and hypomotility.
JZL184 attenuated mechanical and cold allodynia via a CB(1), but not a CB(2), receptor mechanism of action.
JZL184 prolongs depolarization-induced suppression of excitation (DSE) in Purkinje neurons in cerebellar slices and DSI in CA1 pyramidal neurons in hippocampal slices.

物理化学性质&存储条件

分子量	520.49
分子式	C27H24N2O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate

参考文献

1. Long JZ, et al. Nat Chem Biol. 2009 Jan;5(1):37-44.

2. Kinsey SG, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):902-10.

3. Pan B, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.

JZL184 (JZL 184)

生物&药学活性

物理化学性质&存储条件

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JZL184 (JZL 184)

生物&药学活性

物理化学性质&存储条件

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