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首页-小分子抑制剂&激动剂-Others-Other Targets-JYQ-173
JYQ-173

Chemical Structure : JYQ-173

CAS No.:

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JYQ-173 (JYQ173)

货号: PC-22304Not For Human Use, Lab Use Only.

JYQ-173 (JYQ173) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 19 nM, binds covalently and selectively to PARK7 Cys106.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JYQ-173 (JYQ173) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 19 nM, binds covalently and selectively to PARK7 Cys106.

物理化学性质&存储条件

分子量 466.50
分子式 C21H19FN8O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-Cyano-N-(5-(2-fluoro-5-(1H-1,2,3-triazol-1-yl)benzoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrrolidine-3-carboxamide

参考文献

1. Jia Y, et al. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.3c02410.

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