JYL-1421 |CAS:401907-26-4 Probechem Biochemicals

Chemical Structure : JYL-1421

CAS No.: 401907-26-4

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JYL-1421 (SC-0030, JYL1421)

货号: PC-62914Not For Human Use, Lab Use Only.

JYL-1421 (SC-0030) is a potent, competitive TRPV1 receptor antagonist with Ki of 53.5 nM, antagonizes capsaicin-induced calcium uptake with EC50 of 9.2 nM.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JYL-1421 (SC-0030) is a potent, competitive TRPV1 receptor antagonist with Ki of 53.5 nM, antagonizes capsaicin-induced calcium uptake with EC50 of 9.2 nM.
JYL-1421 inhibits capsaicin-evoked substance P, CGRP and somatostatin release from isolated tracheae with IC50 of 0.1-2 uM, decreased capsaicin-induced Ca(2+) accumulation in cultured trigeminal ganglion cells.
JYL-1421 inhibits capsaicin-induced hypothermia, eye wiping movements and reflex hypotension in rats (2 mg/kg, i.p.).

物理化学性质&存储条件

分子量	423.565
分子式	C20H26FN3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[[[[[4-(1,1-dimethylethyl)phenyl]methyl]amino]thioxomethyl]amino]methyl]-2-fluorophenyl]-methanesulfonamide

参考文献

1. Jakab B, et al. Eur J Pharmacol. 2005 Jul 4;517(1-2):35-44.

2. Wang Y, et al. Mol Pharmacol. 2002 Oct;62(4):947-56.

3. Miranda A, et al. Neuroscience. 2007 Sep 21;148(4):1021-32.

JYL-1421 (SC-0030, JYL1421)

生物&药学活性

物理化学性质&存储条件

参考文献

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JYL-1421 (SC-0030, JYL1421)

生物&药学活性

物理化学性质&存储条件

参考文献

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