JYFY-001 | Copper chelator | Probechem Biochemicals

Chemical Structure : JYFY-001

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JYFY-001 (JYFY001)

货号: PC-21438Not For Human Use, Lab Use Only.

JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.

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1 g		Get quote

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生物&药学活性

JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.
JYFY-001 displays weak chelating ability with Na+, K+, Ca2+, Zn2+, Mg2+, or Fe2+
JYFY-001 drastically inhibits the proliferation of two CRC cell lines SW620 and HCT116 with IC50 of 5.95 and 10.41 uM, respectively.
JYFY-001 inhibits glucose metabolism and tumorsphere formation CRC cells.
JYFY-001 (10, 20, and 50 mg/kg) inhibits tumor growth in CRC-transplanted tumor model, increases lymphocyte infiltration in transplanted tumor tissue of CRC.
JYFY-001 plays a synergistic role on PD-1 inhibitor in antitumor activity by increasing the infiltration of lymphocytes in tumor tissue.

物理化学性质&存储条件

分子量	269.32
分子式	C14H11N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(pyridin-3-yl)thieno[3,2-c]pyridin-4-yl)acetamide

参考文献

1. Xiaolong Shi, et al. Drug Dev Res. 2023 Apr;84(2):312-325.

JYFY-001 (JYFY001)

生物&药学活性

物理化学性质&存储条件

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JYFY-001 (JYFY001)

生物&药学活性

物理化学性质&存储条件

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