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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-ERK-JWG-071
JWG-071

Chemical Structure : JWG-071

CAS No.: 2250323-50-1

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JWG-071 (JWG071)

货号: PC-72141Not For Human Use, Lab Use Only.

JWG-071 is a selective Erk5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JWG-071 is a selective ERK5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity.
JWG-071 does not suppress the Brd4 target gene c-Myc, unlike XMD8-85.
JWG-071 inhibits Erk5-dependent c-Myc phosphorylation and degradation, specific Erk5 inhibition drives Dnmt3b expression.

物理化学性质&存储条件

分子量 612.779
分子式 C34H44N8O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

11-(sec-Butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

参考文献

1. Ignazia Tusa, et al. Oncogene. 2018 May;37(19):2601-2614.

2. Charles A C Williams, et al. Cell Rep. 2016 Aug 16;16(7):1820-8.

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