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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-JWD-065
JWD-065

Chemical Structure : JWD-065

CAS No.: 2250287-34-2

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JWD-065 (JWD 065)

货号: PC-73292Not For Human Use, Lab Use Only.

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

物理化学性质&存储条件

分子量 462.572
分子式 C24H26N6O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.

2. Miduturu CV et al. Chem Biol. 2011;18:868–879.

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