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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Wnt-JW74
JW74

Chemical Structure : JW74

CAS No.: 863405-60-1

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JW74 (Wnt inhibitor JW74;JW 74)

货号: PC-45698Not For Human Use, Lab Use Only.

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.
JW74 reduces active β-catenin and downregulates Wnt target genes AXIN2, SP5, and NKD1.
JW74 inhibits tumor growth in mouse xenograft model.

物理化学性质&存储条件

分子量 456.5196
分子式 C24H20N6O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-

参考文献

1. Waaler J, et al. Cancer Res. 2011 Jan 1;71(1):197-205.

2. Stratford EW, et al. Cancer Med. 2014 Feb;3(1):36-46.

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