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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoacylglycerol Lipase (MAGL)-JW 642
JW 642

Chemical Structure : JW 642

CAS No.: 1416133-89-5

JW 642 (JW-642, JW642)

货号: PC-42980Not For Human Use, Lab Use Only.

JW 642 (JW642) is a potent, selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6, 14 and 3.7 nM for mouse, rat and human MAGL, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JW 642 (JW642) is a potent, selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6, 14 and 3.7 nM for mouse, rat and human MAGL, respectively.
JW 642 display little to no activity against human FAAH (IC50>20 uM).

物理化学性质&存储条件

分子量 462.3855
分子式 C21H20F6N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

参考文献

1. Chang JW, et al. Chem Biol. 2012 May 25;19(5):579-88.

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