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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-JW-65
JW-65

Chemical Structure : JW-65

CAS No.: 2763378-71-6

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JW-65 (JW65)

货号: PC-72922Not For Human Use, Lab Use Only.

JW-65 (JW65) is a selective, potent, CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JW-65 (JW65) is a selective, potent,CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3.
    JW-65 shows similar potency and selectivity on TRPC3 channels, but is metabolically much more stable than its precursor, demonstrated by its much longer half-life (>4 h) in mouse, rat, and human liver microsomes when compared to Pyr3.
    JW-65-treated mice showed substantially decreased susceptibility to PTZ-induced seizures in a dose-dependent manner.

    物理化学性质&存储条件

    分子量 445.223
    分子式 C18H13Cl2F3N4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1H-Pyrazole-4-carboxamide, 1-[4-(3,4-dichloro-2-oxo-1(2H)-pyridinyl)phenyl]-N-ethyl-5-(trifluoromethyl)-

    参考文献

    1. Marwa M Nagib, et al. Epilepsia. 2022 Feb 18. doi: 10.1111/epi.17190.

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