Enarodustat hydrochloride (JTZ-951) | HIF-PHD inhibitor

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-JTZ-951 hydrochloride

Chemical Structure : JTZ-951 hydrochloride

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JTZ-951 hydrochloride (JTZ951 hydrochloride, Enarodustat hydrochloride)

货号: PC-60148Not For Human Use, Lab Use Only.

Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
Enarodustat (JTZ-951) increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats.

物理化学性质&存储条件

分子量	376.797
分子式	C17H17ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine hydrochloride

参考文献

1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325.

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JTZ-951 hydrochloride (JTZ951 hydrochloride, Enarodustat hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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JTZ-951 hydrochloride (JTZ951 hydrochloride, Enarodustat hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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