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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-JTZ-951
JTZ-951

Chemical Structure : JTZ-951

CAS No.: 1262132-81-9

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JTZ-951 (JTZ951, SAL0951, Enarodustat)

货号: PC-60147Not For Human Use, Lab Use Only.

Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

规格 价格 库存 数量
5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
Enarodustat (JTZ-951) increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats.

物理化学性质&存储条件

分子量 340.339
分子式 C17H16N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine

参考文献

1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325.

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