JTT-553 benzosulfonate | Probechem Biochemicals

Chemical Structure : JTT-553 benzosulfonate

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JTT-553 benzosulfonate (JTT553)

货号: PC-62952Not For Human Use, Lab Use Only.

JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM).

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生物&药学活性

JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats.

Obesity

Phase 1 Discontinued

物理化学性质&存储条件

分子量	646.682
分子式	C31H33F3N4O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate

参考文献

1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9.

2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8.

JTT-553 benzosulfonate (JTT553)

生物&药学活性

物理化学性质&存储条件

参考文献

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JTT-553 benzosulfonate (JTT553)

生物&药学活性

物理化学性质&存储条件

参考文献

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