JTT-553 | DGAT1 inhibitor | Probechem Biochemicals

Chemical Structure : JTT-553

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JTT-553 (JTT553)

货号: PC-62951Not For Human Use, Lab Use Only.

JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM).
JTT-553 suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats.
JTT-553 also reduces daily food intake and body weight gain in diet-induced obesity rats.

物理化学性质&存储条件

分子量	488.511
分子式	C25H27F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1r,4s)-5'-(4-amino-7,7-dimethyl-2-(trifluoromethyl)-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro[cyclohexane-1,1'-inden]-4-yl)acetic acid

参考文献

1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9.

2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8.

JTT-553 (JTT553)

生物&药学活性

物理化学性质&存储条件

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JTT-553 (JTT553)

生物&药学活性

物理化学性质&存储条件

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