JTT-551 |CAS:776309-04-7 Probechem Biochemicals

Chemical Structure : JTT-551

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JTT-551 (JTT551, JTT 551)

货号: PC-35558Not For Human Use, Lab Use Only.

JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.

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生物&药学活性

JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR.
JTT-551 exhibits clear selectivity against the other PTPs, increases the insulin-stimulated glucose uptake in L6 cells.
JTT-551 enhances the IR phosphorylation of liver and reduces the glucose level in ob/ob mice.
JTT-551 also shows a hypoglycaemic effect without an acceleration of body weight gain in db/db mice.

物理化学性质&存储条件

分子量	605.86
分子式	C34H43N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-(tert-butyl)thiazol-2-yl)methyl)-N-((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)glycine

参考文献

1. Fukuda S, et al. Diabetes Obes Metab. 2010 Apr;12(4):299-306.

2. Ito M, et al. J Diabetes Res. 2014;2014:680348.

JTT-551 (JTT551, JTT 551)

生物&药学活性

物理化学性质&存储条件

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JTT-551 (JTT551, JTT 551)

生物&药学活性

物理化学性质&存储条件

参考文献

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