JTP-117968 |CAS: 2250132-99-9 Probechem Biochemicals

Chemical Structure : JTP-117968

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JTP-117968 (JTP117968)

货号: PC-61852Not For Human Use, Lab Use Only.

JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.

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生物&药学活性

JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
JTP-117968 shows highly selective and GR binding affinity, has neither agonist nor antagonist activity against MT receptors.
JTP-117968 exhibits improved transrepression/transactivation dissociation not only in in vitro assays, but also in in vivo mice experiments.

物理化学性质&存储条件

分子量	520.596
分子式	C31H31F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4b'S,7'R,8a'S)-4b'-benzyl-7'-hydroxy-N-(2-methylpyridin-3-yl)-7'-(trifluoromethyl)-4b',6',7',8',8a',10'-hexahydro-5'H-spiro[cyclopropane-1,9'-phenanthrene]-2'-carboxamide

参考文献

1. Kurimoto T, et al. Eur J Pharmacol. 2017 May 15;803:179-186.

JTP-117968 (JTP117968)

生物&药学活性

物理化学性质&存储条件

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JTP-117968 (JTP117968)

生物&药学活性

物理化学性质&存储条件

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