JTP-109192 | GPR119 agonist | Probechem Biochemicals

Chemical Structure : JTP-109192

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JTP-109192 (JTP109192)

货号: PC-20442Not For Human Use, Lab Use Only.

JTP-109192 (JTP109192) is a potent GPR119 agonist with EC50 of 3.6. 4.5 and 5.2 nM for human, rat and mouse GPR119 respectively (increased intracellular cAMP levels).

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生物&药学活性

JTP-109192 (JTP109192) is a potent GPR119 agonist with EC50 of 3.6. 4.5 and 5.2 nM for human, rat and mouse GPR119 respectively (increased intracellular cAMP levels).
JTP-109192 (0.1-10 uM) significantly increased GLP-1 secretion in GLUTag cells, at 10 uM, 5.6 -fold increase by JTP-109192 was observed as compared with DMSO alone.
JTP-109192 enhanced glucose stimulated insulin secretion (GSIS) in the INS1E cells.
A single administration of JTP-109192 (10 mg/kg) enhanced GSIS at high blood glucose levels in Sprague-Dawley (SD) rats.
A repeated administrations (10 mg/kg) in ZF rats improved glucose metabolism without lack of drug efficacy (tachyphylaxis) and increased glucose infusion rates due to improvement of insulin sensitivity.

物理化学性质&存储条件

分子量	401.59
分子式	C25H39NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5-((5r,8s)-3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)pentyl)oxy)-N,N-dimethylbenzamide

参考文献

1. Hironobu Tadaki, et al. Clin Exp Pharmacol Physiol. 2019 Oct;46(10):910-919.

JTP-109192 (JTP109192)

生物&药学活性

物理化学性质&存储条件

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JTP-109192 (JTP109192)

生物&药学活性

物理化学性质&存储条件

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