JTE-952 |CAS:1255303-54-8 Probechem Biochemicals

Chemical Structure : JTE-952

CAS No.: 1255303-54-8

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JTE-952 (PF-07265804, ARRY382, PF07265804)

货号: PC-36143Not For Human Use, Lab Use Only.

JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM.

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10 mg	￥7280	In stock
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生物&药学活性

JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM.
JTE-952 is also effective against a mouse collagen-induced model of arthritis (mouse CIA-model).

物理化学性质&存储条件

分子量	518.61
分子式	C30H34N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(3-(4-((4-cyclopropylbenzyl)oxy)-3-methoxyphenyl)azetidin-1-yl)(4-((2,3-dihydroxypropoxy)methyl)pyridin-2-yl)methanone

参考文献

1. Ikegashira K, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.

JTE-952 (PF-07265804, ARRY382, PF07265804)

生物&药学活性

物理化学性质&存储条件

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JTE-952 (PF-07265804, ARRY382, PF07265804)

生物&药学活性

物理化学性质&存储条件

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