JTE-852 |CAS:909283-40-5 Probechem Biochemicals

Chemical Structure : JTE-852

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JTE-852 (JTE852)

货号: PC-63130Not For Human Use, Lab Use Only.

JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively.

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生物&药学活性

JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively.
JTE-852 is less potent for Lck (IC50=80 nM), and has IC50 of >300 nM against a kinase panel screenings;.
JTE-852 inhibits the kinase activity of Syk in an intracellular condition, suppresses the secretion of histamine, LTC4/D4/E4, TXA2, PGD2, and IL-13 from mast cells stimulated by IgE-crosslinking with IC50 of 40-100 nM.
JTE-852 attenuates IgG-mediated responses and signs in animal model of autoimmune diseases.

物理化学性质&存储条件

分子量	437.562
分子式	C23H27N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-2-(1-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidin-4-yl)propanoic acid

参考文献

1. Kato T, et al. Eur J Pharmacol. 2017 Apr 15;801:1-8.

2. Kato T, et al. Life Sci. 2017 Dec 15;191:166-174.

3. Kato T, et al. J Vet Med Sci. 2018 Jan 26. doi: 10.1292/jvms.17-0659.

JTE-852 (JTE852)

生物&药学活性

物理化学性质&存储条件

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JTE-852 (JTE852)

生物&药学活性

物理化学性质&存储条件

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