欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-JT010
JT010

Chemical Structure : JT010

CAS No.: 917562-33-5

加入收藏

JT010 (JT-010)

货号: PC-49684Not For Human Use, Lab Use Only.

JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM.
JT010 is highly selective for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 (EC50 values >1 uM).
JT010 (10 nM) failed to stimulate calcium influx in the C621S mutant cells but induced calcium influx in the wild type cells.
JT010 could induce TRPA1-specific pain model. increased the intracellular calcium concentration and extracellular signal-regulated kinase 1/2 phosphorylation, and up-regulated alkaline phosphatase mRNA in human dental pulp cells.
Topical treatment of TRPA1 specific agonist JT010 increased UVB-induced skin pigmentation in guinea pigs.

物理化学性质&存储条件

分子量 354.85
分子式 C16H19ClN2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)acetamide

参考文献

1. Takaya J, et al. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.

2. Heber S, et al. J Neurosci. 2019 May 15;39(20):3845-3855.

3. Tazawa K, et al. Am J Pathol. 2020 Dec;190(12):2417-2426.

4. Wu W, et al. Exp Dermatol. 2022 Oct 27. doi: 10.1111/exd.14693.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: