JT002 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : JT002

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JT002 (JT 002, JT-002)

货号: PC-21079Not For Human Use, Lab Use Only.

JT002 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 6 nM (IL-1β production from hPBMCs), inhibits NLRP3 mediated cytokine production and pyroptosis.

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生物&药学活性

JT002 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 6 nM (IL-1β production from hPBMCs), inhibits NLRP3 mediated cytokine production and pyroptosis.
JT002 potently inhibits IL-1α, IL-1β and IL-18 production with mean IC50 values of 3 nM, 4 nM and 4 nM, respectively, in human peripheral blood mononuclear cells (hPBMCs), with no effect on tumor necrosis factor alpha (TNFα) production up to 1 µM.
JT002 inhibits IL-1β production from human, mouse and rat PBMCs with mean IC50 values of 6, 25 and 159 nM, respectively.
JT002 potently inhibits IL-1β production under the alternative NLRP3 activating conditions with IC50 of 32 nM.
JT002 blocks canonical NLRP3-dependent IL-1β production activated downstream of ATP, nigericin, CHC or MSU with mean IC50 values of 5, 23, 2 and 3 nM, respectively and inhibits non-canonical induced IL-1β production with a mean IC50 value of 30 nM, with no inhibition of IL-1β production after NLRP1, NLRC4 or AIM2 activation at 10 uM.
JT002 blocks NLRP3 inflammasome complex formation and downstream pathway activation.
JT002 (30 mg/kg, oral) prevents disease progression in the Nlrp3A350V/+ knock-in murine model of Muckle Wells syndrome.
JT002 (25 mg/kg) attenuates airway inflammation and airway hyperresponsiveness in a mouse model of IL-17-dependent neutrophilic asthma.

物理化学性质&存储条件

分子量	432.50
分子式	C20H24N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=S(C1=C2OC[C@@H](OC)CN2N=C1)(NC(NC3=C4CCCC4=CC5=C3CCC5)=O)=O

参考文献

1. Ambrus-Aikelin G, et al. Sci Rep. 2023 Aug 19;13(1):13524.

JT002 (JT 002, JT-002)

生物&药学活性

物理化学性质&存储条件

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JT002 (JT 002, JT-002)

生物&药学活性

物理化学性质&存储条件

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