JSH-150 | CAS 2247481-21-4 Probechem Biochemicals

Chemical Structure : JSH-150

CAS No.: 2247481-21-4

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JSH-150 (JSH150;JSH 150)

货号: PC-35688Not For Human Use, Lab Use Only.

JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM).

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5 mg	￥1980	In stock
25 mg	￥3580	In stock
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生物&药学活性

JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM).
JSH-150 also exhibits high selectivity over other 468 kinases/mutants (KINOMEscan S score(1) = 0.01).
JSH-150 displays potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines, dose-dependently inhibits the phosphorylation of RNA Pol II, suppresses the expression of MCL-1 and c-Myc, arreststhe cell cycle and induces the apoptosis in the leukemia cells.
JSH-150 completely suppresses the tumor progression in MV4-11 cell-inoculated xenograft mouse model (10 mg/kg).

物理化学性质&存储条件

分子量	505.078
分子式	C24H33ClN6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-(5-Chloro-2-(((1r,4r)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

参考文献

1. Wang B, et al. Eur J Med Chem. 2018 Oct 5;158:896-916.

JSH-150 (JSH150;JSH 150)

生物&药学活性

物理化学性质&存储条件

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JSH-150 (JSH150;JSH 150)

生物&药学活性

物理化学性质&存储条件

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