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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-JSF-2659
JSF-2659

Chemical Structure : JSF-2659

CAS No.:

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JSF-2659 (JSF2659)

货号: PC-49257Not For Human Use, Lab Use Only.

JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models.

    物理化学性质&存储条件

    分子量 591.537
    分子式 C25H31FN7O7P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (8-(6-fluoro-8-(methylamino)-2-((2-methylpyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-4-yl)-2-oxa-8-azaspiro[4.5]decan-3-yl)methyl dihydrogen phosphate hydrate

    参考文献

    1. Steven Park, et al. Antimicrob Agents Chemother. 2022 Aug 16;e0041422.

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