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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-JSF-2414
JSF-2414

Chemical Structure : JSF-2414

CAS No.: 1673581-19-5

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JSF-2414 (JSF2414)

货号: PC-49256Not For Human Use, Lab Use Only.

JSF-2414 (JSF2414) is a potent, small molecule GyrB/ParE dual binding inhibitor, simultaneously binds to ATP binding regions of DNA gyrase (GyrB) and topoisomerase (ParE) and displays potent in vitro activity against strains of MRSA, VRSA and VISA.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JSF-2414 (JSF2414) is a potent, small molecule GyrB/ParE dual binding inhibitor, simultaneously binds to ATP binding regions of DNA gyrase (GyrB) and topoisomerase (ParE) and displays potent in vitro activity against strains of MRSA, VRSA and VISA.
    JSF-2414 shows prominent growth inhibition against 51 clinical MRSA strains with a modal MIC of 0.031 μg/ml (range 0.002-0.125 μg/ml).
    JSF-2414 also shows potent activity against VISA (MIC range 0.0156-0.156) and VRSA (MIC range 0.0156-0.063) strains.
    JSF-2414 is also highly active against Staphylococcus epidermidis (MIC range 0.002 0.004 μg/ml), Enterococcus faecium (MIC range 0.004-0.008 ug/ml), vancomycin- resistant enterococci (VRE) (MIC range 0.002- >0.5 μg/ml), and E. faecalis (MIC range 0.002-0.008μg/ml), B. anthracis (MIC range 0.049-0.098 μg/ml).
    JSF-2414 also shows activity against a toxigenic C. difficile panel with MIC <0.125 μg/ml.

    物理化学性质&存储条件

    分子量 493.543
    分子式 C25H28FN7O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (8-(6-fluoro-8-(methylamino)-2-((2-methylpyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-4-yl)-2-oxa-8-azaspiro[4.5]decan-3-yl)methanol

    参考文献

    1. Steven Park, et al. Antimicrob Agents Chemother. 2022 Aug 16;e0041422.

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