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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BMX Kinase-JS25
JS25

Chemical Structure : JS25

CAS No.: 2411771-95-2

JS25 (TEC kinase inhibitor JS25)

货号: PC-73285Not For Human Use, Lab Use Only.

JS25 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 3.5 and 5.8 nM for BMX and BTK, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JS25 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 3.5 and 5.8 nM for BMX and BTK, respectively.
    JS25 displays a strong binding affinity against all the members of TEC family, covalently inhibits BMX at Cys496. JS25 demonstrates intracellular target engagement in HEK293 cells (IC50=44.8 nM), 10 times greater than BMX-IN-1.
    JS25 inhibits androgen-receptor positive prostate-cancer cells with GI50 of 6.6 uM.
    JS25 shows synergistic anti-proliferative activity in LNCaP cells in combination with AKT1/2 (AKT inhibitor), Flutamide (androgen receptor antagonist) and LY293002 (PI3K inhibitor).

    物理化学性质&存储条件

    分子量 524.595
    分子式 C29H24N4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-Propenamide, N-[3-methyl-5-[8-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-

    参考文献

    1. João D Seixas, et al. RSC Chem Biol. 2020 Aug 28;1(4):251-262.

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