JS24

Chemical Structure : JS24

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货号: PC-73286Not For Human Use, Lab Use Only.

JS24 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 7.5 and 11.1 nM for BMX and BTK, respectively.

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生物&药学活性

JS24 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 7.5 and 11.1 nM for BMX and BTK, respectively.
JS24 displays a strong binding affinity against all the members of TEC family, covalently inhibits BMX at Cys496.
JS24 inhibits androgen-receptor positive prostate-cancer cells with GI50 of 1.5 uM.
JS24 shows synergistic anti-proliferative activity in LNCaP cells in combination with AKT1/2 (AKT inhibitor), Flutamide (androgen receptor antagonist) and LY293002 (PI3K inhibitor).

物理化学性质&存储条件

分子量	524.595
分子式	C29H24N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. João D Seixas, et al. RSC Chem Biol. 2020 Aug 28;1(4):251-262.

JS24

生物&药学活性

物理化学性质&存储条件

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JS24

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