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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-JS1310
JS1310

Chemical Structure : JS1310

CAS No.: 2247753-73-5

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JS1310 (JS-1310)

货号: PC-49724Not For Human Use, Lab Use Only.

JS1310 (JS-1310) is a specific small-molecule PRMT7 inhibitor with IC50 of 5 uM (human PRMT7), displays no acitivity against type I PRMTs (PRMT1, 3, 4, 6, and 8, IC50 >100 uM) or the type II PRMT5 (IC50=50 uM).

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JS1310 (JS-1310) is a specific small-molecule PRMT7 inhibitor with IC50 of 5 uM (human PRMT7), displays no acitivity against type I PRMTs (PRMT1, 3, 4, 6, and 8, IC50 >100 uM) or the type II PRMT5 (IC50=50 uM).
JS1310 dramaticly decreased the arginine symmetric dimethylation of histone H2A (H2AR3me2s) but not the arginine asymmetric dimethylation of histone H4 (H4R3me2a) in primary leukemia cells isolated from the spleen of CML mice.
JS1310 impaired survival and self-renewal of human CML CD34+ cells, with minimal toxic effects on the survival and self-renewal of normal CD34+ cells.
JS1310 induced apoptosis in the primary CD34+CD38- leukemia cells as well as the quiescent CD34+ leukemia cells purified from individuals with CML, including an imatinib-resistant and relapsed individual harboring T315I/E255K/Y253H BCR-ABL.
JS1310 blocked PRMT7-TRPS1-GLDC signaling axis in long-term engrafted human CML CD34+ cells, inhibited the long-term engraftment capacity of CML CD34+ cells in NCG mice.

物理化学性质&存储条件

分子量 435.46
分子式 C23H22FN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N6-(5-fluoro-2-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl)-2-methylquinoline-4,6-diamine

参考文献

1. Chang Liu, et al. Cell Metab. 2022 Jun 7;34(6):818-835.e7.

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