JRD-SIK1/2i-4

Chemical Structure : JRD-SIK1/2i-4

CAS No.: 2810810-00-3

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货号: PC-21585Not For Human Use, Lab Use Only.

JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.

规格	价格	库存
2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5880	In stock
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.
JRD-SIK1/2i-4 inhibits key intracellular proximal signaling events including reducing phosphorylation of the SIK substrate cAMP response element binding protein (CREB) regulated transcription coactivator 3 (CRTC3).
JRD-SIK1/2i-4 inhibits inflammatory cytokine production in primary human macrophages stimulated with TLR7/8-agonist R848.
JRD-SIK1/2i-4 suppresses IL-2 production by activated primary T cells, ameliorates disease in a murine colitis model.

物理化学性质&存储条件

分子量	388.43
分子式	C21H20N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(2-cyano-5-((1-methylazetidin-3-yl)oxy)pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

参考文献

1. Babbe H, et al. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120.

JRD-SIK1/2i-4

生物&药学活性

物理化学性质&存储条件

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JRD-SIK1/2i-4

生物&药学活性

物理化学性质&存储条件

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