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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-JRC-II-191
JRC-II-191

Chemical Structure : JRC-II-191

CAS No.: 1098209-30-3

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JRC-II-191

货号: PC-22327Not For Human Use, Lab Use Only.

JRC-II-191 is a small-molecule CD4 mimic with Kd of 760 nM for gp120 envelope glycoprotein, inhibits HIV-1 entry by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JRC-II-191 is a small-molecule CD4 mimic with Kd of 760 nM for gp120 envelope glycoprotein, inhibits HIV-1 entry by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor.

物理化学性质&存储条件

分子量 355.84
分子式 C17H23ClFN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-(4-chloro-3-fluorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide

参考文献

1. Haim H, et al. PLoS Pathog. 2009 Apr;5(4):e1000360.

2. Madani N, et al. Structure. 2008;16:1689–1701.

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