JQEZ5 | EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : JQEZ5

CAS No.: 1913252-04-6

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JQEZ5 (JQ5;EZ005;JQEZ-5)

货号: PC-60263Not For Human Use, Lab Use Only.

JQEZ5 (JQ5, EZ005) is a novel potent, selective, SAM-competitive EZH2 inhibitor with IC50 of 80 nM (inhibition of enzymatic function of PRC2).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

JQEZ5 (JQ5, EZ005) is a novel potent, selective, SAM-competitive EZH2 inhibitor with IC50 of 80 nM (inhibition of enzymatic function of PRC2).
JQEZ5 demonstrates acutely reduced level of H3K27me3 without affecting mono- and di-methylation, suppresses the proliferation of EZH2-overexpression H661 and H522 cell lines, more effectively than GSK-126 and GSK-343.
JQEZ5 promotes the regression of EZH2-driven tumors in vivo.

物理化学性质&存储条件

分子量	542.688
分子式	C30H38N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide

参考文献

1. Zhang H, et al. Cancer Discov. 2016 Sep;6(9):1006-21.

2. Frankel AE, et al. Cancer Discov. 2016 Sep;6(9):949-52.

JQEZ5 (JQ5;EZ005;JQEZ-5)

生物&药学活性

物理化学性质&存储条件

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JQEZ5 (JQ5;EZ005;JQEZ-5)

生物&药学活性

物理化学性质&存储条件

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