(+)-JQ-1 |CAS:1268524-70-4 Probechem Biochemicals

Chemical Structure : JQ1

CAS No.: 1268524-70-4

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JQ1 (JQ-1;(+)-JQ-1)

货号: PC-43338Not For Human Use, Lab Use Only.

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.

规格	价格	库存
25 mg	￥1580	In stock
100 mg	￥3580	In stock
500 mg	￥10580	In stock
1 g	￥16800	In stock

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生物&药学活性

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively; induces rapid expression of keratin in treated NMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.

物理化学性质&存储条件

分子量	456.9882
分子式	C23H25ClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-

参考文献

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.

2. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84.

3. Peirs S, et al. Leukemia. 2017 Oct;31(10):2037-2047.

4. Tögel L, et al. Mol Cancer Ther. 2016 Jun;15(6):1217-26.

JQ1 (JQ-1;(+)-JQ-1)

生物&药学活性

物理化学性质&存储条件

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JQ1 (JQ-1;(+)-JQ-1)

生物&药学活性

物理化学性质&存储条件

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