(+)-JQ-1 | BET inhibitor | Probechem Biochemicals

Chemical Structure : JQ1

CAS No.: 1268524-70-4

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JQ1 (JQ-1, (+)-JQ-1)

货号: PC-43338Not For Human Use, Lab Use Only.

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.

规格	价格	库存
5 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
250 mg		Get quote

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生物&药学活性

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
JQ1 induces rapid expression of keratin in treated NMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.

物理化学性质&存储条件

分子量	456.9882
分子式	C23H25ClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-

参考文献

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.

2. Matzuk MM, et al. Cell. 2012 Aug 17;150(4):673-84.

3. Peirs S, et al. Leukemia. 2017 Oct;31(10):2037-2047.

4. Tögel L, et al. Mol Cancer Ther. 2016 Jun;15(6):1217-26.

JQ1 (JQ-1, (+)-JQ-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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JQ1 (JQ-1, (+)-JQ-1)

生物&药学活性

物理化学性质&存储条件

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