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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-JPHM-2-167
JPHM-2-167

Chemical Structure : JPHM-2-167

CAS No.: 1258877-17-6

JPHM-2-167

货号: PC-23635Not For Human Use, Lab Use Only.

JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively.

物理化学性质&存储条件

分子量 504.59
分子式 C30H28N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-([1,1'-biphenyl]-4-yl)-8-((3-methylpyridin-2-yl)methyl)-1-(pyrimidin-2-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione

参考文献

1. Vachal P, et al. J Med Chem. 2012 Apr 12;55(7):2945-59.

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