Nanvuranlat (JPH203, KYT-0353) | LAT1 inhibitor | Probechem Biochemicals

Chemical Structure : JPH203

CAS No.: 1037592-40-7

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JPH203 (Nanvuranlat, KYT-0353, KYT0353, JPH-203)

货号: PC-42276Not For Human Use, Lab Use Only.

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1680	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.
JPH203 inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively.
JPH203 significant inhibits HT-29 tumor growth in vivo.

物理化学性质&存储条件

分子量	472.32066
分子式	C23H19Cl2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-

参考文献

1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.

2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.

3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.

4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.

JPH203 (Nanvuranlat, KYT-0353, KYT0353, JPH-203)

生物&药学活性

物理化学性质&存储条件

参考文献

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JPH203 (Nanvuranlat, KYT-0353, KYT0353, JPH-203)

生物&药学活性

物理化学性质&存储条件

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