JPC0661 | ΔFOSB inhibitor | Probechem Biochemicals

Chemical Structure : JPC0661

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JPC0661 (JPC-0661)

货号: PC-25797Not For Human Use, Lab Use Only.

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生物&药学活性

JPC0661 is a specific small molecule direct inhibitor of AP1 transcription factor ΔdeltaFOSB (ΔFOSB), inhibits FOSB/JUND and ΔFOSB DNA-binding biochemically with IC50 of 9 uM and 52 uM respectively.
JPC0661 inhibits ΔFOSB-mediated transcription in cell-based assays with IC50 of 0.2 uM in luciferase reporter assays.
JPC0661 binds to a groove outside of the DNA-binding cleft of the ΔFOSB/JUND bZIP heterodimer.
JPC0661 disrupts DNA-binding directly, inhibits the ability of ΔFOSB to promote gene expression in cultured cells.
JPC0661 directly disrupts ΔFOSB–DNA interactions in vivo, inhibits ΔFOSB binding to AP1 consensus DNA-binding sites in vivo in an APP mouse model of AD neuropathology.

物理化学性质&存储条件

分子量	347.35
分子式	C15H13N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-amino-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-2-phenoxybenzenesulfonic acid

参考文献

1. McNeme S, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683675.

2. McNeme S, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683721.

JPC0661 (JPC-0661)

生物&药学活性

物理化学性质&存储条件

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JPC0661 (JPC-0661)

生物&药学活性

物理化学性质&存储条件

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