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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-JPC-141 hydrochloride
JPC-141 hydrochloride

Chemical Structure : JPC-141 hydrochloride

CAS No.: 1992775-03-7

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JPC-141 hydrochloride (JPC141 hydrochloride)

货号: PC-22086Not For Human Use, Lab Use Only.

JPC-141 hydrochloride is a potent, selective vesicular monoamine transporter-2 (VMAT2) inhibitor, potently inhibits [3H]dopamine uptake by VMAT2 in striatal vesicles with Ki of 52 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JPC-141 hydrochloride is a potent, selective vesicular monoamine transporter-2 (VMAT2) inhibitor, potently inhibits [3H]dopamine uptake by VMAT2 in striatal vesicles with Ki of 52 nM.
JPC-141 displays 50 to 250-fold greater selectivity for VMAT2 over dopamine, norepinephrine and serotonin plasmalemma transporters.
JPC-141 is 57-fold more selective for inhibiting VMAT2 over [3H]dofetilide binding to hERG channels expressed by HEK293.
JPC-141 prevents the METH-induced reduction in striatal dopamine content in rats.
JPC-141 decreases METH-stimulated locomotor activity in METH-sensitized rats at doses of does not alter locomotor activity in the saline control group.
JPC-141 specifically decreased iv METH self-administration at doses that had no effect on food-maintained responding.

物理化学性质&存储条件

分子量 397.38
分子式 C21H30Cl2N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-methoxyphenethyl)-4-phenethypiperazine hydrochloride

参考文献

1. Chandler CM, et al. Biochem Pharmacol. 2024 Apr 3:116189.

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