JP-153 (JP153) | FAK-paxillin inhibitor | Probechem Biochemicals

Chemical Structure : JP-153

CAS No.: 1802937-26-3

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JP-153 (JP 153, JP153)

货号: PC-60584Not For Human Use, Lab Use Only.

JP-153 (JP153) is a selective FAK-paxillin durotaxis inhibitor, targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

JP-153 (JP153) is a selective FAK-paxillin durotaxis inhibitor, targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.

JP-153 inhibits FAK-FAT domain interaction with paxillin LD4 and LD2 domains, without affecting FAK catalytic activity

JP-153 potently inhibits VEGF-induced proliferation and migration.

JP-153 inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.

物理化学性质&存储条件

分子量	365.385
分子式	C21H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,4,5-trimethoxyphenyl)-1,4-dihydro-2H-naphtho[1,2-d][1,3]oxazin-2-one

参考文献

1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13.
2. Al-Hilal TA, et al. Nat Cell Biol. 2025 Sep 9. doi: 10.1038/s41556-025-01697-8.

JP-153 (JP 153, JP153)

生物&药学活性

物理化学性质&存储条件

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JP-153 (JP 153, JP153)

生物&药学活性

物理化学性质&存储条件

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