JP-153 |CAS:1802937-26-3 Probechem Biochemicals

Chemical Structure : JP-153

CAS No.: 1802937-26-3

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JP-153 (JP 153;JP153)

货号: PC-60584Not For Human Use, Lab Use Only.

JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.
JP-153 potently inhibits VEGF-induced proliferation and migration.
JP-153 inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.

物理化学性质&存储条件

分子量	365.385
分子式	C21H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,4,5-trimethoxyphenyl)-1,4-dihydro-2H-naphtho[1,2-d][1,3]oxazin-2-one

参考文献

1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13.

JP-153 (JP 153;JP153)

生物&药学活性

物理化学性质&存储条件

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JP-153 (JP 153;JP153)

生物&药学活性

物理化学性质&存储条件

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