JP-11646 (JP11646)

Chemical Structure : JP-11646

CAS No.: 1902983-63-4

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货号: PC-63142Not For Human Use, Lab Use Only.

JP-11646 (JP11646) is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively.

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5 mg	￥4580	In stock
10 mg	￥7280	In stock
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生物&药学活性

JP-11646 (JP11646) is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively.
JP-11646 shows less potency for other kinases in a kinase selectivity panel.
JP-11646 exhibits 4-760-fold greater suppression of MM proliferation and viability than ATP-competitive PIM inhibitors.
JP-11646 significant reduces tumor burden and increases median survival in xenogeneic myeloma murine models.

物理化学性质&存储条件

分子量	459.568
分子式	C25H25N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-5-((2-(((1r,4r)-4-((naphthalen-1-ylmethyl)amino)cyclohexyl)amino)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

参考文献

1. Nair JR, et al. Leukemia. 2017 Aug;31(8):1715-1726.

JP-11646 (JP11646)

生物&药学活性

物理化学性质&存储条件

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JP-11646 (JP11646)

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物理化学性质&存储条件

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