欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-JNU-0921
JNU-0921

Chemical Structure : JNU-0921

CAS No.:

加入收藏

JNU-0921 (JNU0921)

货号: PC-22968Not For Human Use, Lab Use Only.

JNU-0921 is a specfiic, small molecule CD137 (4-1BB/TNFRSF9) agonist with EC50 of 64 nM in cell-based luciferase assays, activates both human and mouse CD137, directly binds the extracellular domain of CD137, induces CD137 oligomerizationand activates CD137 signaling.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JNU-0921 is a specfiic, small molecule CD137 (4-1BB/TNFRSF9) agonist with EC50 of 64 nM in cell-based luciferase assays, activates both human and mouse CD137, directly binds the extracellular domain of CD137, induces CD137 oligomerizationand activates CD137 signaling.
JNU-0921 treatment stimulated transcription levels of IFN-γ and Granzyme B (GZMB) in JC-luc cells.
JNU-0921 treatment promoted the proliferation of both CD8+ and CD4+ splenic T cells from WT mice in a similar manner to agonistic anti-CD137 antibody (aCD137), but not enhance proliferation of CD137 knockout (KO) T cells.
JNU-0921 treatment increased the levels of CD25 and CD69 in a CD137-dependent manner, up-regulated the expression of effector cytokines in both CD8+ and CD4+ T cells, including IL-2 and IFN-γ.
JNU-0921 promoted the proliferation of CD8+ T cells and CD4+ T cells in human peripheral blood cells.
JNU-0921 binding to CD137 led to recruitment of TRAF2 and TRAF3 to form signaling complex, activates the NF-κB signaling pathway.
JNU-0921 (50 mg/kg per day, gavage) effectively shrinks tumors and rewires tumor immune microenvironment in MC38 xenograft mouse model.

物理化学性质&存储条件

分子量 316.32
分子式 C19H12N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(naphthalen-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid

参考文献

1. Lu Liu, et al. Sci Adv. 2024 Aug 23;10(34):eadp8647.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: