JNT-517 | SLC6A19 inhibitor | Probechem Biochemicals

Chemical Structure : JNT-517

CAS No.: 2837993-05-0

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JNT-517 (Repinatrabit, JNT517)

货号: PC-25026Not For Human Use, Lab Use Only.

JNT-517 (Repinatrabit, JNT517) is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 47 nM against human SLC6A19 in the isoleucine transport assay.

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2 mg	￥1880	In stock
5 mg	￥2980	In stock
10 mg	￥4780	In stock
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100 mg		Get quote

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生物&药学活性

JNT-517 (Repinatrabit, JNT517) is a highly selective, first-in-class, orally bioavailable inhibitor of SLC6A19 (B0AT1) with IC50 of 47 nM against human SLC6A19 in the isoleucine transport assay.
JNT-517 (Repinatrabit) potently inhibitsthe transport of glutamine in human intestinal epithelial cells with endogenous expression levels of SLC6A19 (IC50 = 81 nM).
JNT-517 (Repinatrabit) does not inhibit either SLC1A5, SLC7A5, or SLC6A8 at 35 uM.
JNT-517 (Repinatrabit) also shows negligible activity against mouse SLC6A19 (IC50>11.8 uM).
JNT-517 (Repinatrabit) is found to be safe and well tolerated and increased the urinary excretion of Phe in a phase 1 healthy volunteer study.

物理化学性质&存储条件

分子量	418.39
分子式	C18H22F4N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(1-Cyclopropyl-3-(2-fluoro-4-(trifluoromethoxy)benzyl)ureido)piperidine-1-carboxamide

参考文献

1. Wobst HJ, et al. JCI Insight. 2024 Nov 8;9(21):e182876.

JNT-517 (Repinatrabit, JNT517)

生物&药学活性

物理化学性质&存储条件

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JNT-517 (Repinatrabit, JNT517)

生物&药学活性

物理化学性质&存储条件

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