JNK3 inhibitor JC16I

Chemical Structure : JNK3 inhibitor JC16I

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货号: PC-23102Not For Human Use, Lab Use Only.

JNK3 inhibitor JC16I is a potent, selective covalent JNK3 inhibitor with IC50 of 5.31 nM, >160-fold selectivity for JNK3 over JNK1/2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

JNK3 inhibitor JC16I is a potent, selective covalent JNK3 inhibitor with IC50 of 5.31 nM, >160-fold selectivity for JNK3 over JNK1/2.
JC16I showed enhanced and long-lasting inhibition against cellular JNK3.
JC16I selectively suppressed the abnormal activation of JNK3 signaling and sufficiently exhibited neuroprotective effect in Parkinson's diseases (PD) models.

物理化学性质&存储条件

分子量	577.47
分子式	C29H26Cl2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-5-(4-(4-(((4-chloro-1H-indazol-3-yl)amino)methyl)benzoyl)piperazine-1-carbonyl)phenyl)acrylamide

参考文献

1. Liang Ouyang, et al. Angew Chem Int Ed Engl. 2024 Sep 14:e202411037.