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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-JNK-JNK2 inhibitor J27
JNK2 inhibitor J27

Chemical Structure : JNK2 inhibitor J27

CAS No.: 2998941-15-2

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JNK2 inhibitor J27 (JNK2-IN-1)

货号: PC-27652Not For Human Use, Lab Use Only.

JNK2 inhibitor J27 (JNK2-IN-1) is a selective c-Jun N-terminal kinase 2 (JNK2) inhibitor with Kd of 79.2 uM, decreases the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6, IC50=0.22 μM) through NF-κB/MAPK pathway.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JNK2 inhibitor J27 (JNK2-IN-1) is a selective c-Jun N-terminal kinase 2 (JNK2) inhibitor with Kd of 79.2 uM, decreases the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6, IC50=0.22 μM) through NF-κB/MAPK pathway.

物理化学性质&存储条件

分子量 522.56
分子式 C30H26N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-4-methyl-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide

参考文献

1. Jing Liao, et al. J Med Chem. 2023 Sep 14;66(17):12304-12323.

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