JNK1 inhibitor E1

Chemical Structure : JNK1 inhibitor E1

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货号: PC-27744Not For Human Use, Lab Use Only.

JNK1 inhibitor E1 is a potent and selective inhibitor of JNK1 with IC50 of 2.7 nM, inhibits c-Jun phosphorylation with IC50 of <1 uM, exerts significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevents TGF-β-induced epithelial-to-mesenchymal transition in vitro.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JNK1 inhibitor E1 is a potent and selective inhibitor of JNK1 with IC50 of 2.7 nM, inhibits c-Jun phosphorylation with IC50 of <1 uM, exerts significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevents TGF-β-induced epithelial-to-mesenchymal transition in vitro.

物理化学性质&存储条件

分子量	501.39
分子式	C22H25BrN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-bromo-2-((4-methoxyphenyl)amino)pyrimidin-4-yl)amino)-5-(2-(dimethylamino)ethoxy)benzamide

参考文献

1. Yi Huang, et al. J Med Chem. 2024 Oct 10;67(19):17713-17737.