JNK1 inhibitor 14

Chemical Structure : JNK1 inhibitor 14

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货号: PC-27737Not For Human Use, Lab Use Only.

JNK1 inhibitor 14 is a selective and potent inhibitor of c-Jun N-terminal kinase 1 (JNK1) with IC50 of 0.8 nM, 8.3 nM and 1.3 nM for JNK1, JNK2 and JNK3, shows 10-fold selectivity over JNK3.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JNK1 inhibitor 14 is a selective and potent inhibitor of c-Jun N-terminal kinase 1 (JNK1) with IC50 of 0.8 nM, 8.3 nM and 1.3 nM for JNK1, JNK2 and JNK3, shows 10-fold selectivity over JNK3.
JNK1 inhibitor 14 exhibits significant dose-dependent inhibition of p-c-Jun across four different cell lines.
JNK1 inhibitor 14 induces epithelial-mesenchymal transformation (EMT) for developing pathological cell models.
JNK1 inhibitor 14 shows potential anti-fibrotic effects.

物理化学性质&存储条件

分子量	509.36
分子式	C23H21BrN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-((4-(2-oxa-5-azabicyclo [2.2.1] heptane-5-carbonyl) phenyl) amino)-5-bromopyrimidin-4-yl) amino) benzamide

参考文献

1. Shuhua Ren, et al. Bioorg Med Chem Lett. 2025 Feb 1:116:130044.