JNJ 41876666 |CAS:1259026-14-6 Probechem Biochemicals

Chemical Structure : JNJ 41876666

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JNJ 41876666 (JNJ-41876666;JNJ41876666)

货号: PC-60719Not For Human Use, Lab Use Only.

JNJ 41876666 (JNJ-41876666) is a potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM.

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生物&药学活性

JNJ 41876666 (JNJ-41876666) is a potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM.
JNJ 41876666 exhibits minimal effect on the enzyme activity of CYP isoforms 3A4, 1A2, 2D6, 2C9, and 2C19 (IC50>10 uM).
JNJ 41876666 completely prevents icilin-induced WDS at an oral dose of 10 mg/kg, exhibits potent in vitro functional activity and robust oral efficacy in an inflammatory model of neuropathic pain at relatively low plasma levels.
JNJ 41876666 also reduces proliferation rates and proliferative fraction in prostate cancer cells.

物理化学性质&存储条件

分子量	503.873
分子式	C23H20ClF6N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro[4.5]dec-2-ene hydrochloride

参考文献

1. Valero ML, et al. PLoS One. 2012;7(12):e51825.

2. Parks DJ, et al. J Med Chem. 2011 Jan 13;54(1):233-47.

JNJ 41876666 (JNJ-41876666;JNJ41876666)

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物理化学性质&存储条件

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JNJ 41876666 (JNJ-41876666;JNJ41876666)

生物&药学活性

物理化学性质&存储条件

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