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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-JNJ303
JNJ303

Chemical Structure : JNJ303

CAS No.: 878489-28-2

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JNJ303 (JNJ 303)

货号: PC-63222Not For Human Use, Lab Use Only.

JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents).

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50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JNJ303 is a potent, specific delayed rectifier potassium current (IKs) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents).
JNJ303 prolongs QT, strongly increases field potential (FP) duration.

物理化学性质&存储条件

分子量 440.983
分子式 C21H29ClN2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide

参考文献

1. Wrobel E, et al. Nat Commun. 2016 Oct 12;7:12795.

2. Braam SR, et al. Stem Cell Res. 2013 Jan;10(1):48-56.

4. Guns PJ, et al. J Pharmacol Toxicol Methods. 2012 Sep;66(2):125-34.

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