JNJ0966 | MMP-9 inhibitor | Probechem Biochemicals

Chemical Structure : JNJ0966

CAS No.: 315705-75-0

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JNJ0966 (JNJ-0966)

货号: PC-26813Not For Human Use, Lab Use Only.

JNJ0966 is a potent, highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) with IC50 of 440 nM in proMMP-9 activation assays.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

JNJ0966 is a potent, highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) with IC50 of 440 nM in proMMP-9 activation assays.
JNJ0966 shows no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and does not inhibit activation of the highly related MMP-2 zymogen.
JNJ0966 inhibits proMMP-9 maturation, reduced proMMP-9 maturation through intermediate states to active fully processed enzyme.
JNJ0966 reduces motor symptoms in mouse experimental autoimmune encephalomyelitis (EAE) and penetrates into the brain.

物理化学性质&存储条件

分子量	360.45
分子式	C16H16N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((2-Methoxyphenyl)amino)-4'-methyl-[4,5'-bithiazol]-2'-yl)acetamide

参考文献

1. Scannevin RH, et al. J Biol Chem. 2017 Oct 27;292(43):17963-17974.

2. Stegmuller C, et al. Neurobiol Dis. 2025 Aug;212:106978.

JNJ0966 (JNJ-0966)

生物&药学活性

物理化学性质&存储条件

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JNJ0966 (JNJ-0966)

生物&药学活性

物理化学性质&存储条件

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