JNJ-A07 | DENV inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-A07

CAS No.: 2135640-93-4

加入收藏

JNJ-A07 ((+)-JNJ-A07)

货号: PC-72500Not For Human Use, Lab Use Only.

JNJ-A07 is a highly potent, highly specific dengue virus (DENV) inhibitor targeting the NS3-NS4B interaction.

规格	价格	库存
5 mg	￥2780	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JNJ-A07 is a highly potent, highly specific dengue virus (DENV) inhibitor targeting the NS3-NS4B interaction.
JNJ-A07 displays high potency with nanomolar to picomolar activity against a panel of 21 clinical isolates that represent the natural genetic diversity of known genotypes and serotypes.
JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between viral proteins NS3 and NS4B.
JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.

物理化学性质&存储条件

分子量	578.969
分子式	C28H26ClF3N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (579 mg/mL)
Chemical Name/SMILES	(+)-4-[3-[[1-(4-Chlorophenyl)-2-[2,3-dihydro-6-(trifluoromethoxy)-1H-indol-1-yl]-2-oxoethyl]amino]-5-methoxyphenoxy]butanoic acid

参考文献

1. Suzanne J F Kaptein, et al. Nature. 2021 Oct;598(7881):504-509.

JNJ-A07 ((+)-JNJ-A07)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JNJ-A07 ((+)-JNJ-A07)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.