JNJ-8003 | RSV polymerase inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-8003

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JNJ-8003 (JNJ 8003)

货号: PC-21284Not For Human Use, Lab Use Only.

JNJ-8003 is a highly potent, selective, non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase with IC50 of 0.67 nM, shows EC50 of 0.15 nM in RSV subgenomic replicon assays.

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生物&药学活性

JNJ-8003 is a highly potent, selective, non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase with IC50 of 0.67 nM, shows EC50 of 0.15 nM in RSV subgenomic replicon assays.
JNJ-8003 targets the RSV L + P polymerase complex in both Flashplate and gel-based 4-mer primer extension assays using the recombinant L and P viral proteins.
JNJ-8003 does not inhibit human DNA polymerases α, β, and γ, human mitochondrial RNA polymerase, and human RNA polymerase II (IC50>100 uM). JNJ-8003 inhibits viral RNA replication and transcription at the initiation and early elongation stage.
JNJ-8003 binds within the capping domain of RSV L.

物理化学性质&存储条件

分子量	576.52
分子式	C28H25F5N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-methoxy-3-methyl-N-(3,3,3-trifluoro-2-(5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl)-2-hydroxypropyl)cinnoline-6-carboxamide

参考文献

1. Xiaodi Yu, et al. Commun Biol. 2023 Oct 21;6(1):1074.

JNJ-8003 (JNJ 8003)

生物&药学活性

物理化学性质&存储条件

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JNJ-8003 (JNJ 8003)

生物&药学活性

物理化学性质&存储条件

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