JNJ-77242113 | IL-23 receptor inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-77242113

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JNJ-77242113 (JNJ-2113)

货号: PC-22797Not For Human Use, Lab Use Only.

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10 mg		Get quote
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100 mg		Get quote

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生物&药学活性

JNJ-77242113 is a highly potent, selective, oral peptide inhibitor of IL-23 receptor with Kd of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling.
JNJ-77242113 inhibits IL-23–induced interferon (IFN)γ production in NK cells, and in blood from healthy donors and psoriasis patients with IC50 of 18.4, 11 and 9 pM, respectively.
JNJ-77242113 inhibits ex vivo IL-23–stimulated IL-17A production.
JNJ-77242113 inhibited IL-23–induced skin thickening and IL-17A, -17F and -22 gene induction in IL-23–induced rat skin inflammation model.

物理化学性质&存储条件

分子量	1898.19
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S3,1,S3,6-cyclo[N-acetyl-3-sulfanyl-L-valyl-L-asparaginyl-L-threonyl-7-methyl-L-tryptophyl-N6-acetyl-L-lysyl-3-sulfanyl-L-valyl-O-(2-aminoethyl)-L-tyrosyl-3-(naphthalen-2-yl)-L-alanyl-4-aminooxan-4-carbonyl-L-α-glutamyl-L-asparaginyl-3-(pyridin-3-yl)-L-alanyl-N2-methylglycinamide

参考文献

1. Fourie AM, et al. Sci Rep. 2024 Jul 30;14(1):17515.

JNJ-77242113 (JNJ-2113)

生物&药学活性

物理化学性质&存储条件

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JNJ-77242113 (JNJ-2113)

生物&药学活性

物理化学性质&存储条件

参考文献

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