JNJ-74856665 (JNJ-6665) | DHODH inhibitor | Probechem Biochemicals

Chemical Structure : JNJ-74856665

CAS No.: 2641340-35-2

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JNJ-74856665 (JNJ74856665, JNJ-6665)

货号: PC-49779Not For Human Use, Lab Use Only.

JNJ74856665 (JNJ-6665) is an orally available, potent and selective DHODH inhibitor with IC50 of 0.4 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JNJ74856665 (JNJ-6665) is an orally available, potent and selective DHODH inhibitor with IC50 of 0.4 nM.
JNJ74856665 inhibited proliferation of MOLM-13, OCI-AML3, HL60 and THP-1 AML cell lines with low nanomolar IC50 values in vitro, demonstrated induction of CD11b and CD14 differentiation marker mRNA levels in four cell lines.
JNJ-74856665 mediated significant activity in decreasing leukemic burden and increasing life span across subcutaneous (MOLM-13 and OCI-AML3) and disseminated (MOLM-13) xenografts, respectively, in vivo.

物理化学性质&存储条件

分子量	436.49
分子式	C24H25FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-ethyl-2-(7-fluoro-4-isopropyl-2-(2-methoxyphenyl)quinolin-6-yl)-5-(hydroxymethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

参考文献

1. Patent WO2021084500 A1. 2. DeRatt LG, et al. J Med Chem. 2024 Jul 11;67(13):11254-11272.

JNJ-74856665 (JNJ74856665, JNJ-6665)

生物&药学活性

物理化学性质&存储条件

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JNJ-74856665 (JNJ74856665, JNJ-6665)

生物&药学活性

物理化学性质&存储条件

参考文献

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