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首页-小分子抑制剂&激动剂-Others-Other Targets-JNJ-74856665
JNJ-74856665

Chemical Structure : JNJ-74856665

CAS No.: 2641340-35-2

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JNJ-74856665 (JNJ74856665)

货号: PC-49779Not For Human Use, Lab Use Only.

JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 of 0.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 of 0.4 nM.
    JNJ74856665 inhibited proliferation of MOLM-13, OCI-AML3, HL60 and THP-1 AML cell lines with low nanomolar IC50 values in vitro, demonstrated induction of CD11b and CD14 differentiation marker mRNA levels in four cell lines.
    JNJ-74856665 mediated significant activity in decreasing leukemic burden and increasing life span across subcutaneous (MOLM-13 and OCI-AML3) and disseminated (MOLM-13) xenografts, respectively, in vivo.

    物理化学性质&存储条件

    分子量 436.49
    分子式 C24H25FN4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-ethyl-2-(7-fluoro-4-isopropyl-2-(2-methoxyphenyl)quinolin-6-yl)-5-(hydroxymethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

    参考文献

    1. Patent WO2021084500 A1.
    2. DeRatt LG, et al. J Med Chem. 2024 Jul 11;67(13):11254-11272.

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